Clinical Research
Resting-state functional magnetic resonance imaging of supramarginal gyrus-cerebellum circuit in obsessive-compulsive disorder
Zhao Qingjiang, Zhang Haisan, Wang Bi, Yao Nan, Yang Yongfeng, Lyu Luxian, Zhang Hongxing, Wang Xiaoyue
Published 2019-02-20
Cite as Chin J Behav Med & Brain Sci, 2019, 28(2): 127-132. DOI: 10.3760/cma.j.issn.1674-6554.2019.02.006
Abstract
ObjectiveRegional homogeneity (ReHo) and functional connectivity (FC) were used to study obsessive-compulsive disorder(OCD), and to explore the mechanism of OCD in resting state.
MethodResting-state functional magnetic resonance imaging (RS-fMRI) was performed in 55 patients with OCD(OCD group) and 50 normal controls (control group) matched by sex, age, nationality and education.The data and screening abnormal brain areas were analyzed and compared by DPARSFA2.3 and Rest software in OCD group.Whole brain FC analysis was performed with abnormal brain areas as seed points.
ResultCompared with the control group, ReHo in right thalamus (MNI: x=9, y=-24, z=6, t=4.3217) and left superior marginal gyrus (MNI: x=-45, y=-30, z=27, t=3.6320) increased and ReHo in right caudate nucleus (MNI: x=3, y=15, z=9, t=-3.1687) decreased in obsessive-compulsive disorder group, and the difference was statistically significant(P<0.05). Using left superior marginal gyrus, right thalamus and right caudate nucleus as seed voxels, the whole brain FC analysis showed that there were abnormal functional connections between bilateral cerebellar foot 1/2 area and left supramarginal gyrus, right thalamus and right caudate nucleus (P<0.05) and the left supramarginal gyrus-bilateral cerebellum feet 1 area-right thalamic circuit and left supramarginal gyrus-bilateral cerebellum feet 1, 2-right caudate nucleus-right thalamic circuit existed in OCD group.
ConclusionThe left supramarginal gyrus-bilateral cerebellum feet 1 area-right thalamic circuit and left supramarginal gyrus-bilateral cerebellum feet 1, 2-right caudate nucleus-right thalamic circuit may play an important role in the mechanism of OCD.
Key words:
Obsessive compulsive disorder; Regional homogeneity; Functional connection; Supramarginal gyrus-cerebellum circuit
Contributor Information
Zhao Qingjiang
Radiology Department, Henan Mental Hospital(The Second Affiliated Hospital of XinXiang Medical University), XinXiang 453002, China
Xinxiang Key Laboratory of Multimodal Brain Imaging, XinXiang 453002, China
Zhang Haisan
Radiology Department, Henan Mental Hospital(The Second Affiliated Hospital of XinXiang Medical University), XinXiang 453002, China
Xinxiang Key Laboratory of Multimodal Brain Imaging, XinXiang 453002, China
Wang Bi
Radiology Department, Henan Mental Hospital(The Second Affiliated Hospital of XinXiang Medical University), XinXiang 453002, China
Xinxiang Key Laboratory of Multimodal Brain Imaging, XinXiang 453002, China
Yao Nan
Radiology Department, Henan Mental Hospital(The Second Affiliated Hospital of XinXiang Medical University), XinXiang 453002, China
Yang Yongfeng
Henan Key Lab of Biological Psychiatry, XinXiang 453002, China
Lyu Luxian
Henan Key Lab of Biological Psychiatry, XinXiang 453002, China
Zhang Hongxing
School of Psychology, Xinxiang Medical University, XinXiang 453002, China
Wang Xiaoyue
Radiology Department, Henan Mental Hospital(The Second Affiliated Hospital of XinXiang Medical University), XinXiang 453002, China
