To explore the influencing factors of the onset of autism spectrum disorder in male children.

Totally 151 male children with autism spectrum disorder were selected as case group and 119 healthy male children matched with the age of the case group in the same administrative region were taken as the control group.All children were assessed with the questionnaire for children's autism etiology and risk factors.

(1)The differences in children having anorexia and partial eclipse(χ²=50.763, P<0.01), father's age during pregnancy(χ²=11.441, P=0.043), place of pregnancy(χ²=50.763, P<0.01), hypertension of pregnancy(χ²=5.693, P=0.026), intrauterine hypoxia(χ²=9.332, P=0.002), umbilical cord around the neck(χ²=18.483, P<0.01), parents smoking and drinking history during pregnancy(χ²=13.660, P=0.008), parental smoking(χ²=12.901, P=0.005)and alcohol consumption(χ²=8.386, P=0.039)during pregnancy, birth height of child(χ²=8.870, P=0.031), amniotic fluid pollution(χ²=4.561, P=0.043), participation time of artificial feeding, major caregivers, delayed development indicators in infants and young children and whether or not the harmonious parent-child relationship were statistically significant(P<0.05). (2)Children with anorexia and partial diet (OR=12.284, 95%CI=2.768-54.507), living in rural areas during pregnancy (OR=17.251, 95%CI=1.899-156.745), parents' history of smoking and drinking (OR=6.191, 95%CI=1.678-22.838), and intrauterine hypoxia during pregnancy (OR=38.859, 95%CI=2.944-512.930) may be risk factors for male autism spectrum disorder.

To correct children's anorexia bias, improve the living environment in pregnancy, reduce pregnancy complications and avoid exposure to tobacco and alcohol pollution during maternal pregnancy can be an effective entry point for the prevention and control of autism spectrum disorders in male children.

Autism spectrum disorder; Influencing factors; Male; Children