Depressive Disorder
Trajectory analysis of single-drug therapy for first-episode major depression disorder
Yuan Xinsong, Zhu Xiao, Shen Chun, Luo Qiang, Shi Shenxun
Published 2019-06-20
Cite as Chin J Behav Med & Brain Sci, 2019,28(6): 493-498. DOI: 10.3760/cma.j.issn.1674-6554.2019.06.003
Abstract
ObjectiveTo analyze the treatment trajectory and revelant factors of serotonin reuptake inhibitors (SSRIs) in patients with first-episode major depression after single-drug treatment.And to provide ideas for early optimal treatment.
MethodsThis study was a real-world study in which 82 untreated outpatients with first-episode depression were enrolled for SSRIs monotherapy.The Eysenck Personality Test (EPQ), the Liebowitz Social Anxiety Scale (LSAS), Yale -Brown Forced Scale (Y-BOCS), Social Function Deficit Scale (SDSS) were used to assess all patients at baseline.Then the patients were treated with SSRIs monotherapy.Patients who did not achieve a HAMD-17 20% reduction rate in the second week switched to receive another SSRIs monotherapy application.Follow-up to the 12th week to analyze treatment trajectory and identify factors associated with treatment trajectory.
ResultsThe psychotism personality trait (B=-0.287, 95%CI=-0.701~-0.071, P=0.009) and age (B=0.099, 95%CI=0.014~0.244, P=0.017) were related to treatment trajectories.The psychotism personality trait did not directly influence the treatment trajectory but influenced the treatment indirectly through agitation and the effect value was 0.016, which accounted for 10.76% of the total effect.Social anxiety and avoidance, depression, anxiety, obsessive-compulsive symptoms and social dysfunction at baseline were not associated with antidepressant efficacy.
ConclusionPsychoticism can predict the efficacy of antidepressants treatment as a mediator at the second week of treatment.
Key words:
Major depressive disorder; Psychotism; Trajectory analysis; Early improvement; Eisenck personality test
Contributor Information
Yuan Xinsong
Department of Psychiatry, Huashan Hospital Affiliated to Fudan University, Shanghai 200040; Department of Psychiatry, Nanjing Brain Hospital, Nanjing 210029
Zhu Xiao
Department of Psychiatry, Huashan Hospital Affiliated to Fudan University, Shanghai 200040
Shen Chun
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China
Luo Qiang
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Ministry of Education), Fudan University, Shanghai 200433, China
Shi Shenxun
Department of Psychiatry, Huashan Hospital Affiliated to Fudan University, Shanghai 200040
