Allogeneic hematopoietic cell transplantation for malignant hematological diseases in patients older than 50 years of age
WU Xiao-jin, MA Xiao, LIU Yue-jun, ZHAO Ye, HU Xiao-hui, ZHOU Hai-xia, HAN Yue, TANG Xiao-wen, FU Zheng-zheng, QIU Hui-ying, SUN Ai-ning, WU De-pei
Published 2011-08-20
Cite as Chin J Organ Transplant, 2011,32(08): 485-487. DOI: 10.3760/cma.j.issn.0254-1785.2011.08.010
Abstract
Objective To investigate the efficiency and safety of allogeneic hematopoietic cell transplantation for malignant hematological diseases in patients older than 50 yeas of age. Methods From May 2002 to January 2010, 35 patients (> 50 years) with malignant hematological diseases received allogeneic hematopoietic cell transplantation. In 35 patients, 18 patients were conditioned with non-myeloablative regimen and 17 patients with myeloablative regimen. The outcome,engraftment and prognosis of allogeneic hematopoietic cell transplantation were analyzed. Results The hematopoetic reconstitution was achieved in 32 of 35 patients. The median time of granulocyte count exceeding 0. 5 × 109/L was 12 days and the that of platelet count exceeding 20 × 109/L was 17days. The cumulative incidence of aGVHD was 48. 6 %, and 37. 9 % patients developed cGVHD.The estimate probability of cumulative survival at 5 years was 48. 5 %, The estimate probability of cumulative mortality rate was 51.5 %, and the estimated transplant-related mortality was 22. 9 %.The relapse rate was 11.4 %. There was significant difference except for the incidence of cGVHD.Conclusion Allogeneic hematopoietic cell transplantation may be appropriate for older patients with malignant hematological diseases.
Key words:
Hematopoietic stem cell transplantation; Hematologic neoplasms
Contributor Information
WU Xiao-jin
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
MA Xiao
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
LIU Yue-jun
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
ZHAO Ye
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
HU Xiao-hui
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
ZHOU Hai-xia
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
HAN Yue
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
TANG Xiao-wen
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
FU Zheng-zheng
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
QIU Hui-ying
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
SUN Ai-ning
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China
WU De-pei
Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215007,China