Objective By implantating endoluminal sleeve devices at different length,We sought to investigate the influence on energy metabolism,glucose regulation and the expression of glucagon-like peptide-1 receptor (GLP-1R) in the pancreas of diet-induced obese rats.Methods Sprague-Dawley rats were randomly divided into four groups:sham-operated animnals (SO,n =8),rats implanted with a 1 cm endoluminal sleeve devices (ELS) device (ELS-1,n =10),4 cm ELS (ELS-4,n=8),or 10 cm ELS (ELS-10; n =9).We examined the effects of ELS implanted in rats on body weight,energy expenditure,insulin resistance,levels of GLP-1 and so on,comparing them with sham-operated (SO) rats.After 8 weeks,reverse transcriptase-polymerase chain reaction (RT-PCR) was used to analysis the mRNA levels of GLP-1 receptor in the pancreas.To determine the extent of duodenal exclusion required to influence metabolic outcomes and glucose control,we compared the effects of implanting 10,4,or 1 cm ELS with SO.Results ELS-10 rats exhibited 13％ higher total and 9％ higher resting energy expenditure than SO con-trols (P ＜ 0.05).ELS-10 rats also exhibited enhanced fasting GLP-1 secretion and improved GLP-1 receptor expression (P ＜ 0.05),insulin resistance (P ＜ 0.05) with a significantly 14％ lower weight loss (P ＜0.05).While implantation of 4 or 1 cm ELS devices had no effect on energy expenditure and limited effects on glucose homeostasis (P ＞ 0.05).Conclusion Here we report that fully excluding the duode-num with an ELS increased total and resting energy expenditure,improved glucose regulation,as well as the GLP-1 receptor in pancreatic.Exclusion of only a portion of the duodenum resulted in more modest weight loss.