Objective To discuss the clinical effectiveness of vacuum sealing drainage (VSD) used in the treatment of fulminant acute pancreatitis (FAP) after necrosectomy and laparostomy.Methods A retrospective analysis was performed on the clinical data of 4 patients with FAP using VSD after necrosectomy and laparostomy.Results Four patients with FAP received VSD treatment after necrosectomy and laparostomy.VSD effectively washed out necrotic tissue and promoted the formation of clean cavity around the pancreas after 2 weeks postoperatively.This technique has superiority including infection prevention,edema-eliminating,protecting intra-abdominal organs and surgical incision,and promoting healing.This technique can obviously reduce the frequency of dressing change and its amount,and workload of doctors and nurses.Conclusion Using VSD is an effective method to control pancreatic leakage,eliminate necrotic tissue,and protect intra-abdominal organs and surgical incision after necrosectomy and laparostomy for the patients with large amount of effusion and intra-abdominal organ edema.