Clinical Research
Relationship of circulating tumor cell status with coagulation and clinicopathological variables in patients with bladder cancer treated with radical cystectomy
Guoxian Zhang, Jinjin Feng, Wen Zhu, Yan Wang, Qingwei Wang, Jianguo Wen
Published 2019-02-08
Cite as Chin J Exp Surg, 2019, 36(2): 333-335. DOI: 10.3760/cma.j.issn.1001-9030.2019.02.045
Abstract
ObjectiveTo investigate the relationship between circulating tumor cell (CTC) counts with plasma D-dimer (D-D), fibrinogen (FIB), platelet (PLT) and clinicopathological features in patients with bladder cancer treated with radical cystectomy.
MethodsThe CTC counts, coagulation indexes and clinicopathological data in 85 cases of muscle invasive bladder cancer undergoing radical cystectomy were analyzed. The occurrence of venous thromboembolism (VTE) during the follow-up period (90 days) was recorded. According to the CTC counts, patients were divided into two groups: CTC negative group (CTC=0, n=58) and CTC positive group (CTC≥1, n=27). The relationship of CTC counts with coagulation indexes and clinicopathological variables was analyzed.
ResultsThere were 4 cases of postoperative VTE in CTC positive group (4.7%) during the follow-up period. The D-D level in CTC positive group was significantly higher than in CTC negative group (P<0.05), and there was no significant difference in FIB and PLT between two groups. There was no significant difference in TNM stage, age, gender and ECOG scores between two groups. The surgical margin positive rate and incidence of local lymph node metastasis in CTC positive group were significantly higher than in CTC negative group (P<0.05). Plasma D-D levels and positive surgical margin were the independent predictive factors for positive CTC counts.
ConclusionPresence of CTC may be associated with VTE. CTC positive group has higher D-D level, positive surgical margin and local lymph node metastasis.
Key words:
Bladder cancer; Radical cystectomy; Circulating tumor cell; D-dimer; Venous thromboembolism
Contributor Information
Guoxian Zhang
Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Jinjin Feng
The Open Laboratory of Hunan Provincial High-school Clinical Medical Key Disciplines, Zhengzhou 450052, China
Wen Zhu
Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Yan Wang
Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Qingwei Wang
Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Jianguo Wen
Department of Urology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
