Clinical Research
Research on the relationship between the expression of mitofusin 2 and phosphatidylinositol transfer membrane-associated protein 3 in intrahepatic metastasis of hepatocellular carcinoma
Zeyu Lin, Yaorong Peng, Chunxia Liu, Zhenyu Zhou, Heyun Zhang, Wenbin Li, Yunle Wan
Published 2019-04-08
Cite as Chin J Exp Surg, 2019, 36(4): 737-739. DOI: 10.3760/cma.j.issn.1001-9030.2019.04.045
Abstract
ObjectiveTo investigate the relationship between expression of mitofusin 2 (Mfn2) and phosphatidylinositol transfer membrane-associated protein 3 (PITPNM3) in the intrahepatic metastasis in hepatocellular carcinoma (HCC).
MethodsA total of 149 patients with HCC patients who underwent hepatectomy were enrolled in this study. The clinical follow-up data and pathological tissue sections were collected. Immunohistochemical staining was performed for Mfn2 and PITPNM3 in pathological section. The relationship between the expression of Mfn2 and PITPNM3 immunohistochemical staining scores and clinicopathological data in patients were analyzed.
ResultsIn the negative expression group of Mfn2, 54.55% patients’ PITPNM3 expressions are strongly positive. In the strongly positive expression group of Mfn2, 52.17% patients’ PITPNM3 expressions are negative. The expression of Mfn2 is highly negative correlated with PITPNM3 expression; Patients have a high histological grade, high rate of intrahepatic metastasis, late clinical stage and bad prognosis with high expression of PITPNM3, 56.34% patients are intrahepatic metastasis; Patients have a relatively low histological grade, low rate of intrahepatic metastasis, early clinical stage and good prognosis with high expression of Mfn2, only 14.08% patients are intrahepatic metastasis.
ConclusionMfn2 may be a key protein that inhibits intrahepatic metastasis of HCC.
Key words:
Mitofusin 2; Phosphatidylinositol transfer membrane-associated protein 3; Hepatocellular carcinoma; Intrahepatic metastasis
Contributor Information
Zeyu Lin
Department of Hepatobiliary Surgery, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China
Yaorong Peng
Department of Biliopancreatic surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
Chunxia Liu
Department of Ultrasonography, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
Zhenyu Zhou
Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
Heyun Zhang
Department of Hepatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
Wenbin Li
Department of Biliopancreatic surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China
Yunle Wan
Department of Hepatobiliary Surgery, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China
