Clinical Research
The effects of single incision laparoscopic radical gastrectomy on the immune function during perioperative period
Jiaxing Wang, Longkai Huang, Qingliang He
Published 2019-07-08
Cite as Chin J Exp Surg, 2019, 36(7): 1295-1298. DOI: 10.3760/cma.j.issn.1001-9030.2019.07.043
Abstract
ObjectiveTo investigate the effect of single incision laparoscopic radical gastrectomy in the immune function during perioperative period.
MethodsTwenty patients of single incision laparoscopic radical operation (SILS) for gastric cancer and 20 Gastric cancer Patients who underwent t conventional laparoscopic surgery (CLS) from June 2016 to June 2017 were selected as SILS group and CLS group respectively. The immunological indicators were detected before and after surgery. The performance of operation in two groups were compared.
ResultsThere was no significant difference in the baseline data between the two groups (t=0.804, 0.555, 1.203, 0.833, P>0.05). The total incision length of the SILS group was shorter than that of the CLS group [ (5.11±1.53) cm vs. (10.02±2.31) cm, t=22.581, P<0.01], and shorter time to ambulation [ (1.01±0.59) d vs. (2.81±0.74) d, t=12.247, P<0.01], postoperative pain was light (χ2=9.690, P<0.05). Compared with preoperative, the ET, CRP and IL-6 level of the two groups increased first and then decreased (t=5.287, 6.946, 8.169, P<0.05). The CD4+ CD25+ forkhead box P3(Foxp3)+ /CD4+ levels in the SILS group were higher than those in the CLS group (t=5.264, 3.951, P<0.05). There was no local recurrence and distant metastasis rate in the whole group for 12 months.
ConclusionSingle incision laparoscopic treatment of gastric cancer has the advantages of quicker recovery, lighter pain, lighter immunosuppression and good cosmetic effect compared with the CLS group.
Key words:
Single incision laparoscopy; Gastric cancer; CD4+ CD25+ Foxp3+ /CD4+
Contributor Information
Jiaxing Wang
Department of Gastrointestinal Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China
Longkai Huang
The First Clinical Medical College of Fujian Medical University, Fuzhou 350005, China
Qingliang He
Department of Gastrointestinal Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China