Clinical Research
BRAFV600E/telomerase reverse transcriptase protein expression in lung metastasis of papillary thyroid carcinoma and clinical significance
Ling Chen, Youzhi Zhu, Ke Zheng, Huihao Zhang, Kunlin Wu, Lingjun Kong, Wei Lin, Caiqin Mo, Jiajie Xue, Xiangjin Chen
Published 2019-08-08
Cite as Chin J Exp Surg, 2019, 36(8): 1455-1458. DOI: 10.3760/cma.j.issn.1001-9030.2019.08.036
Abstract
ObjectiveTo investigate the protein expression of BRAFV600E/telomerase reverse transcriptase (TERT) in patients with papillary thyroid cancer (PTC) and its correlation with lung metastasis.
MethodsThe tumor tissues of 716 patients with PTC were collected. The expression of BRAFV600E and TERT was detected by immunohistochemistry, and their clinical pathological features were analyzed.
ResultsIn tumor tissues of these PTC patients, 62.3% (446/716) expressed BRAFV600E protein, 30.9% (221/716) expressed TERT protein, and 18% (129/716) co-expressed BRAFV600E and TERT proteins. Multivariate analysis revealed that special subtype of papillary carcinoma, maximal diameter of tumor, lateral cervical lymph node metastasis, and co-expression of BRAFV600E/TERT proteins were independent risk factors of PTC lung metastasis. Tumor maximum diameter, lateral cervical lymph node metastasis and co-expression of BRAFV600E/TERT proteins had a high diagnostic accuracy [area under curve (AUC)>0.7] in predicting lung metastasis in PTC patients.
ConclusionThe specific subtype of papillary carcinoma, tumor maximum diameter, lateral cervical lymph node metastasis and co-expression of BRAFV600E/TERT proteins were independent risk factors for PTC pulmonary metastasis.
Key words:
Papillary thyroid carcinoma; Lung metastasis; BRAFV600E; Telomerase reverse transcriptase
Contributor Information
Ling Chen
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
Youzhi Zhu
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
Ke Zheng
Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
Huihao Zhang
Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
Kunlin Wu
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
Lingjun Kong
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
Wei Lin
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
Caiqin Mo
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
Jiajie Xue
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
Xiangjin Chen
Department of Thyroid and Breast Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350009, China
