Clinical Research
Expression of human cartilage glycoprotein 39 in peripheral blood and tissues in renal cell carcinoma
Dai Haitao, Cheng Fan, Liu Changmao, Liu Yuanhua, Zhang Zhong, Peng Changwei, Wang Zhongyu, Zheng Jiang, Li Chenglong
Published 2020-01-08
Cite as Chin J Exp Surg, 2020,37(01): 166-168. DOI: 10.3760/cma.j.issn.1001-9030.2020.01.048
Abstract
ObjectiveTo investigate the expression of human cartilage glycoprotein 39 (YKL-40) in renal clear cell carcinoma and peripheral blood, and to analyze its correlation with prognosis.
MethodsA total of 110 patients who underwent radical nephrectomy were enrolled as the observation group, and 50 patients with normal physical examination results were enrolled as the control group. The renal clear cell carcinoma tissues and adjacent tissues were taken after operation, and the expression level of YKL-40 mRNA was detected by real-time fluorescent quantitative polymerase chain reaction (FQ-PCR).
ResultsThe level of YKL-40 [(186.9±15.7) μg/L] in the peripheral blood of the observation group before surgery was significantly higher than that of the control group [(115.1±12.5) μg/L] and after surgery [(146.3±13.5) μg/L, t=20.565, 28.478, P<0.05]. There was a correlation between YKL-40 in peripheral blood and lymph node metastasis (t=5.047, P<0.05). A total of 98 patients were followed up. The success rate was 89.1%, the median follow-up time was 47.5 months, and the 3-year survival rate was 62.34%. Patients with elevated YKL-40 in peripheral blood had shorter OS than patients with reduced blood YKL-40 (χ2=6.296, P<0.05), while there was no significant difference in YKL-40 in cancer tissues and OS (χ2=0.030, P>0.05). Multivariate Cox analysis showed that Fuhrman classification [OR(95%CI): 2.335(1.359-10.656)], lymph node metastasis [OR(95%CI): 1.854(1.289-7.659)] and peripheral blood YKL-40 [OR(95%CI): 1.335(1.185-6.987)] were independent factors of OS (P<0.05).
ConclusionThe level of YKL-40 in peripheral blood of patients with renal clear cell carcinoma is elevated and closely related to OS, which may be a prognostic marker. There was no increase in the level of YKL-40 in cancer tissues, and serum YKL-40 may not be derived from cancer cells.
Key words:
YKL-40; Renal clear cell carcinoma; Overall survival
Contributor Information
Dai Haitao
Department of Urology, People’s Hospital of Wuhan University, Hubei Provincial People’s Hospital, Wuhan 430060, China
Cheng Fan
Department of Urology, People’s Hospital of Wuhan University, Hubei Provincial People’s Hospital, Wuhan 430060, China
Liu Changmao
Department of Urology, the First Affiliated Hospital of Changjiang University, Jingzhou First People’s Hospital, Jingzhou 434000, China
Liu Yuanhua
Department of Urology, the First Affiliated Hospital of Changjiang University, Jingzhou First People’s Hospital, Jingzhou 434000, China
Zhang Zhong
Department of Urology, the First Affiliated Hospital of Changjiang University, Jingzhou First People’s Hospital, Jingzhou 434000, China
Peng Changwei
Department of Urology, the First Affiliated Hospital of Changjiang University, Jingzhou First People’s Hospital, Jingzhou 434000, China
Wang Zhongyu
Department of Urology, the First Affiliated Hospital of Changjiang University, Jingzhou First People’s Hospital, Jingzhou 434000, China
Zheng Jiang
Department of Urology, the First Affiliated Hospital of Changjiang University, Jingzhou First People’s Hospital, Jingzhou 434000, China
Li Chenglong
Department of Urology, People’s Hospital of Wuhan University, Hubei Provincial People’s Hospital, Wuhan 430060, China
