Review
Recent advances in liquid biopsy for predicting prognosis of hepatocellular carcinoma
Qianqian He, Hao Xing, Mingcheng Guan, Chao Li, Lanqing Yao, Hong Zhu, Tian Yang
Published 2021-12-08
Cite as Chin J Exp Surg, 2021, 38(12): 2555-2557. DOI: 10.3760/cma.j.cn421213-20210327-01107
Abstract
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors globally. The rapid progression in HCC contributes to the high fatality rates and poor overall prognosis, with the 5-year survival of less than 18%. For this reason, several methods, including HCC staging systems, are often used to evaluate the prognosis of patients with HCC. However, due to the high heterogeneity of HCC, these traditional tools can not accurately predict its prognosis. In recent years liquid biopsy has become a hot topic, Liquid biopsy is a minimally invasive technology for the detection of molecular components (e.g., circulating tumor cells, circulating cell-free nucleic acids, and exosomes) in body fluid, eventually reflecting the tumor status and its prognosis. Herein, the current review aimed to explore the potential role of liquid biopsy in the prognosis of HCC.
Key words:
Liquid biopsy; Hepatocellular carcinoma; Prognostication; Circulating tumor cells; Circulating cell-free nucleic acids; Exosomes
Contributor Information
Qianqian He
Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Hao Xing
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital of Naval Medical University, Shanghai 200438, China
Mingcheng Guan
Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Chao Li
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital of Naval Medical University, Shanghai 200438, China
Lanqing Yao
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital of Naval Medical University, Shanghai 200438, China
Hong Zhu
Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
Tian Yang
Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital of Naval Medical University, Shanghai 200438, China
