Clinical Research
The changes in effective connectivity in the precentral gyrus after transcranial magnetic stimulation
Chen Ying, Zhu Yulian, Hu Ruiping, Tang Xinwei, Yang Qing, Cao Yue, Tian Shan, Li Ce, Wu Junfa, Wu Yi
Published 2021-03-25
Cite as Chin J Phys Med Rehabil, 2021, 43(3): 211-214. DOI: 10.3760/cma.j.issn.0254-1424.2021.03.004
Abstract
ObjectiveTo investigate any change in the effective connectivity between the bilateral anterior central gyruses after transcranial magnetic stimulation (TMS).
MethodsTwenty-one healthy subjects were examined using resting state functional magnetic resonance imaging (rs-fMRI) before and after receiving continuous theta burst stimulation (cTBS). The brain atlas of the Institute of Automation of the Chinese Academy of Sciences was used for fine partitioning of the bilateral anterior central gyruses. Granger causality analysis was used to compare any changes in the effective connectivity between them.
ResultsAfter the cTBS inhibited the right M1 area, significant changes in effective connectivity among the sub-regions of the bilateral M1 area were observed. The effective connectivity of the right upper limb to the left upper limb and the left head to face were weakened, while that of the left upper limb to the right head, as well as of the face to the right upper limb was enhanced.
ConclusionFor people whose right M1 area has been inhibited by cTBS, the effective connectivity changes in both upper limb functional areas of the M1 region reflect inter-hemispheric inhibition. Opposite changes were found in the trunk and upper limbs.
Key words:
Transcranial magnetic stimulation; Precentral gyrus; Brain connectivity
Contributor Information
Chen Ying
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Zhu Yulian
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Hu Ruiping
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Tang Xinwei
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Yang Qing
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Cao Yue
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Tian Shan
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Li Ce
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Wu Junfa
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
Wu Yi
Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China
