Original Article
Differentiating true progession from pseudoprogression in patients with gliobastomas using dynamic contrast-enhanced MRI
Xibin Xia, Pingsheng Hu, Zhengwen He, Fengjiao Yang, Feng Bi, Qiang Lu, Xiaoping Yu
Published 2017-08-20
Cite as J Chin Physician, 2017, 19(8): 1152-1155. DOI: 10.3760/cma.j.issn.1008-1372.2017.08.008
Abstract
ObjectiveTo investigate the clinical application and manifestation of dynamic contrast-enhanced MRI (DCE-MRI) in differentiating true progession from pseudoprogression in patients with gliobastomas.
MethodsTwenty five glioma patients were treated with postoperative concurrent chemoradiotherapy and enrolled in this study. All patients were underwent DCE-MRI using a 1.5T scanner. Fifteen patients were confirmed by secondary pathology or clinical and imaging follow-up of patients with gliomas true progession (TP), 10 patients were pseudoprogress (PP). Nonparametric Mann-Whitney test was used to compare perfusion parameters between two groups (TP and PP), were used for receiver operating characteristic (ROC) curve analysis to clear if these parameters can be the indicators to differentiate true progession from pseudoprogression.
ResultsKtrans(volume transfer constant ), Ve (fractional volume of extravascular extracellular) values between TP and PP glioma groups were statistically significant, Ktransand Ve values were significantly higher in the TP group than in the PP group (P<0.05). The areas under the ROC curve are 0.990 and 0.847, respectively. Kep (efflux rate constant) value, Vp (fractional volume of plasma) value in the identification of glioma TP group and PP group was not statistically significant (P>0.05).
ConclusionsDCE-MRI can be used to identify glioma TP and PP, Ktrans value and Ve value have clinical significance.
Key words:
Magnetic resonance imaging; Glioma/DI; Diagnosis, differential
Contributor Information
Xibin Xia
Department of Diagnostic Radiology, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha 410013, China
Pingsheng Hu
Department of Diagnostic Radiology, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha 410013, China
Zhengwen He
Department of Neurosurgery, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha 410013, China
Fengjiao Yang
Department of Head and Neck Radiotherapy, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha 410013, China
Feng Bi
Department of Diagnostic Radiology, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha 410013, China
Qiang Lu
Department of Diagnostic Radiology, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha 410013, China
Xiaoping Yu
Department of Diagnostic Radiology, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha 410013, China
