Study on fatigue symptoms and related factors in Parkinson 's disease patients
Runcheng He, Qiying Sun, Jifeng Guo, Qian Xu, Yun Tian, Beisha Tang, Xinxiang Yan
Abstract
ObjectiveTo investigate the prevalence of fatigue symptoms and investigate its related factors in patients with Parkinson's disease (PD).
MethodsThe Parkinson's Fatigue Scale (PFS-16) was used to assess the fatigue status of 453 PD patients. These patients were divided into fatigue group (mean PFS-16≥3.3 defined as fatigue) and non-fatigue group. All of them completed the assessment of the relevant scale.
ResultsAmong 453 PD patients, there were 169 patients (37.3%) in fatigue group and 284 patients (62.7%) in non-fatigue group. Unified Parkinson's disease Rating Scale (UPDRS) and Hoehn-Yahr (H-Y) staging in fatigue group were significantly higher than non-fatigue group (P<0.05). Motor symptoms, mental and emotional status and daily living ability are positively correlated with fatigue symptoms.
ConclusionsThe motor symptoms and non-motor symptoms are more serious in PD patients with fatigue. The motor symptoms, mental and emotional status, daily living ability and Hoehn-Yahr (H-Y) stage are the main related factors of fatigue symptoms in PD patients.
Key words:
Parkinson disease/CO; Fatigue/CO
Contributor Information
Runcheng He
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
Qiying Sun
Department of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
Jifeng Guo
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
Qian Xu
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
Yun Tian
Department of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
Beisha Tang
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
Xinxiang Yan
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China