Monographic Research·Parkinson's Disease Comorbidity
Study on the clinical features and related factors of cognitive impairment in Parkinson's disease
Changmin Wan, Qiying Sun, Qian Xu, Yun Tian, Xinxiang Yan, Beisha Tang, Jifeng Guo
Published 2018-01-20
Cite as J Chin Physician, 2018, 20(1): 12-15. DOI: 10.3760/cma.j.issn.1008-1372.2018.01.04
Abstract
ObjectiveTo explore the correlated factors and clinical features of cognitive impariment in parkinson's disease (PD).
MethodsA total of 419 patients with PD were collected from Xiangya Hospital of Centre-South University during Mar 1st, 2017 to Nov 30th, 2017. The cognitive functions of patients were assessed with the Mini-Mental State Examination (MMSE), and the basic information and the motor symptoms of 419 PD patients were selected at the same time. The PD patients were classified into three groups according to the MMSE score: PD with no cognitive impairment (PD-NC), mild cognitive impairment in PD (PD-MCI), and Dementia in PD (PD-D). The data were analyzed by SPSS 20.0.
ResultsThere were 156 patients with PD-MCI (37.2%) and 64 patients with PD-D (15.3%). The difference of sex and disease duration among three groups were not statistically significant (P>0.05). The significant difference was found among PD-D, PD-MCI, and PD-NC groups in age of onset, age, educational attainment, Unified Parkinson's disease Rating Scale (UPDRS)-Ⅱscore, UPDRS-Ⅲ score and Hoehn-Yahr stage (P<0.05). There were significant differences among three groups in MMSE score and its items (P<0.01). Logistics regression analysis found that the age of onset, educational attainment, and Hoehn-Yahr stage were the risk factors of cognitive impairment in PD patients (P<0.05).
ConclusionsCognitive im-pairment is common in PD patients, and it is relevant to the age of onset, educational attainment and the severity of illness of PD patients.
Key words:
Parkinson disease/CO; Cognition disorders/CO
Contributor Information
Changmin Wan
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
Qiying Sun
Department of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
Qian Xu
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
Yun Tian
Department of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
Xinxiang Yan
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
Beisha Tang
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
Jifeng Guo
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China
National Clinical Research Center for Geriatric Diseases, Central South University, Changsha 410008, China
