Original Article
Effect of MRI combined with serum levels of CA153, CEA and CYFRA21-1 on the diagnostic efficacy of breast cancer patients
Li Xiaohui, Sun Honghong, Zhang Qiujuan, Zhou Xiaoqian, Tang Yaping, Wu Hongmei
Published 2018-09-20
Cite as J Chin Physician, 2018,20(9): 1338-1341,1347. DOI: 10.3760/cma.j.issn.1008-1372.2018.09.016
Abstract
ObjectiveTo investigate the effect of color magnetic resonance imaging (MRI) combined with serum levels of carbohydrate antigen 153 (CA153), carcinoembryonic antigen (CEA) and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) on the diagnostic efficacy of breast cancer patients.
MethodsFrom December 2015 to December 2017, 80 cases of breast cancer in our hospital were selected as the observation group. Another 98 patients with benign breast diseases as control group A, and 94 healthy women as control group B. The serum levels of CA153, CEA and CYFRA21-1in the three groups were measured by electrochemiluminescence and the level of the above serum indexes in patients with different disease stages (stage Ⅰ to Ⅱ, Ⅲ to Ⅳ) in the observation group were compared. The 3 groups were examined by color Doppler high frequency ultrasound. The specificity, sensitivity and accuracy of color Doppler ultrasound combined with serum CA153, CEA and CYFRA21-1 or detecting alone in the diagnosis of breast cancer analyzed.
ResultsThere were significant differences in the levels of serum CA153, CEA and CYFRA21-1 in the 3 groups (P<0.05), and the level of serum CA153, CEA and CYFRA21-1 in the observation group was higher than that in the control group A and the control group B (P<0.05). The levels of serum CA153, CEA and CYFRA21-1 in patients in stage Ⅲ to Ⅳ of the observation group were higher than those in patients in stage Ⅰ to Ⅱ (P<0.05). The sensitivity and accuracy of color Doppler ultrasound combined with serum CA153, CEA and CYFRA21-1 in the diagnosis of breast cancer were 96.25% (77/80) and 84.93% (231/272), respectively, which were all higher than those of serum CA153, CEA and CYFRA21-1 alone (P<0.05). And the sensitivity of combined diagnosis was higher than that of color Doppler high frequency ultrasound alone (P<0.05).
ConclusionsColor Doppler ultrasound combined with serum levels of CA153, CEA and CYFRA21-1 can significantly improve the sensitivity and accuracy of breast cancer diagnosis, reduce the risk of missed diagnosis, and provide a strong basis for diagnosis and treatment of breast cancer.
Key words:
Breast neoplasms/DI; Magnetic resonance imaging; CA-15-3 Antigen/BL; Carcinoembryonic antigen/BL; Keratin-19/BL; Antigens, neoplasm
Contributor Information
Li Xiaohui
Department of Medical Imaging, Second Affiliated Hospital of Xi′an Jiao Tong University, Xi′an 710004, China
Sun Honghong
Department of Medical Imaging, Second Affiliated Hospital of Xi′an Jiao Tong University, Xi′an 710004, China
Zhang Qiujuan
Department of Medical Imaging, Second Affiliated Hospital of Xi′an Jiao Tong University, Xi′an 710004, China
Zhou Xiaoqian
Department of Medical Imaging, Second Affiliated Hospital of Xi′an Jiao Tong University, Xi′an 710004, China
Tang Yaping
Department of General Surgery, Second Affiliated Hospital of Xi′an Jiao Tong University, Xi′an 710004, China
Wu Hongmei
Department of Medical Imaging, Second Affiliated Hospital of Xi′an Jiao Tong University, Xi′an 710004, China
