Monographic Research · New Ultrasonic Technologies and Application Progress
Correlation between shear wave velocity of renal parenchyma and TGF-β1 in chronic allograft nephropathy
Sha He, Chunyan Cao, Yi Zheng, Yue Song, Jing Wang
Published 2019-03-20
Cite as J Chin Physician, 2019, 21(3): 327-330. DOI: 10.3760/cma.j.issn.1008-1372.2019.03.003
Abstract
ObjectiveTo evaluate the change of shear wave velocity (SWV) of renal parenchyma and serum level of transforming growth factor beta 1 (TGF-β1) in the patients with chronic allograft nephropathy (CAN), and further evaluate the correlation between them.
MethodsA total of 60 patients with chronic allograft nephropathy confirmed by renal biopsy were selected and divided into three groups according to the degree of interstitial fibrosis and tubular atrophy of the transplanted kidney: group C1 (renal cortex involvement <25%, n=20), group C2(renal cortex involvement accounted for 26%-50%, n=20), group C3(renal cortex involvement >50%, n=20). 30 renal transplant recipients with normal renal function were enrolled for control group. The SWV of the renal were measured by virtual touch tissue quantification (VTQ) and the serum level of TGF-β1 were detected by enzyme linked immunosorbent assay (ELISA) in each group.
ResultsCompared with control group, the SWV and serum TGF-β1 in case groups were significantly higher (P<0.05). SWV measured values: group C3 was the highest, group C2 was middle one and group C1 was the lowest (P<0.05). Statistically significant difference in serum TGF-β1 was observed among these three groups (P<0.05). The renal SWV and serum TGF-β1 had a significant positive correlation (r=0.631, P<0.05).
ConclusionsBoth renal SWV and serum TGF-β1 increase as CAN progressed, which have high value in the diagnosis and treatment of CAN.
Key words:
Kidney transplantation; Kidney diseases; Ultrasonography, doppler, color; Transforming growth factor beta1
Contributor Information
Sha He
Department of Ultrasound, Maternal and Child Health Hospital of Hubei, Wuhan 430070, China
Chunyan Cao
Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China
Yi Zheng
Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China
Yue Song
Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China
Jing Wang
Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China
