Monographic Research • Trauma Repair and Scar Plastic
Bioinformatics analysis of angiogenesis-related miRNAs in endothelial progenitor cell exosomes
Wu Xiong, Anmeng Sun, Yi Huang, Wenjuan Quan, Fengjiao You, Xulong Yang, Hongwei Lan, Honghui Su, Jianda Zhou
Published 2019-04-20
Cite as J Chin Physician, 2019, 21(4): 499-502. DOI: 10.3760/cma.j.issn.1008-1372.2019.04.005
Abstract
ObjectiveBy taking usage of bioinformatics screening methods, this medical research aimed at exploring how the miRNAs in endothelial progenitor cell exosomes relate to the regulation of angiogenesis.
MethodsmiRNAs in endothelial progenitor cells exosomes and angiogenesis-related miRNA was intersected from the existing database to obtain the candidates of miRNA molecules related to angiogenesis in endothelial progenitor exosomes.
Results160 and 50 miRNAs in endothelial progenitor cell candidates were obtained through experimental data analysis and literature searching respectively. 600 candidates of angiogenesis-related miRNAs were obtained through literature searching; the top 20 with the highest frequency were selected out. Finally, 9 miRNA candidates (miR-126, miR-21, miR-221, miR-92a, miR-199a, miR-210, miR-214, miR-155, miR-146a) that may be highly expressed in endothelial progenitor exosomes and associated with angiogenesis were obtained for the following research.
ConclusionsBased on data analysis and literature searching, bioinformatics could screen out the target miRNAs for follow-up studies easily and reliably, it is worthy to be widely applied and popularized.
Key words:
Endothelial progenitor cells; Exosomes; MicroRNAs; Neovascularization, physiologic; Bioinformatics
Contributor Information
Wu Xiong
Department of Burn and Plastic Surgery, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
Anmeng Sun
Hunan University of Chinese Medicine, Changsha 410208, China
Yi Huang
Hunan University of Chinese Medicine, Changsha 410208, China
Wenjuan Quan
Hunan University of Chinese Medicine, Changsha 410208, China
Fengjiao You
Hunan University of Chinese Medicine, Changsha 410208, China
Xulong Yang
Department of Burn and Plastic Surgery, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
Hongwei Lan
Department of Burn and Plastic Surgery, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
Honghui Su
Department of Plastic and Cosmetic Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China
Jianda Zhou
Department of Plastic and Cosmetic Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, China
