Monographic Research • Clinical Application of Interventional Ultrasound and Contrast-enhanced Ultrasound
Diagnostic value of fine needle aspiration cytology combined with serum calcitonin for medullary thyroid carcinoma
Chen Yan, Sun Desheng, Zhong Jieyu, Lin Xiaona, Hu Zhengming, Liu Jun
Published 2019-08-20
Cite as J Chin Physician, 2019,21(8): 1136-1138. DOI: 10.3760/cma.j.issn.1008-1372.2019.08.005
Abstract
ObjectiveTo investigate the value of fine-needle aspiration cytology (FNAC) combined with serum calcitonin in the diagnosis of medullary thyroid carcinoma (MTC).
MethodsRetrospective analysis of the serum calcitonin and FANC results in 17 cases of MTC confirmed by pathological examination. The diagnostic value of the two methods alone and in combination for MTC were compared.
Results13 of the 17 MTC patients (13/17, 76.5%) underwent fine needle aspiration biopsy before surgery, 11 cases (11/13, 84.6%) diagnosed as thyroid malignant tumor, 7 of whom were diagnosed or suspected of MTC (7/13, 53.8%). Serum calcitonin levels increased in different degrees in 16 patients. The sensitivity of the two methods combined in the diagnosis of MTC was 92.3% (12/13).
ConclusionsFNAC is an important diagnostic method for the evaluation of thyroid nodules, but it is not sensitive to the diagnosis of MTC. Serum calcitonin is highly sensitive but not universally available. Compared with FNAC alone, FNAC combined with the serum calcitonin examination may significantly improve the detection rate of MTC preoperative and reduce missed diagnosis.
Key words:
Ultrasonography; Biopsy, fine-needle; Calcitonin; Thyroid neoplasms; Carcinoma, medullary
Contributor Information
Chen Yan
Department of Ultrasound, Peking University Shenzhen Hospital, Shenzhen 518036, China
Sun Desheng
Department of Ultrasound, Peking University Shenzhen Hospital, Shenzhen 518036, China
Zhong Jieyu
Department of Ultrasound, Peking University Shenzhen Hospital, Shenzhen 518036, China
Lin Xiaona
Department of Ultrasound, Peking University Shenzhen Hospital, Shenzhen 518036, China
Hu Zhengming
Department of Ultrasound, Peking University Shenzhen Hospital, Shenzhen 518036, China
Liu Jun
Department of Pathology, Peking University Shenzhen Hospital, Shenzhen 518036, China