Review
The functions and mechanisms of BLACAT1 in malignant tumors
Xu Shuwan, Xia Haoming, Gao Zewei, Huang Rongju, Tang Enyu, Jiang Xingming
Published 2020-03-20
Cite as J Chin Physician, 2020,22(03): 469-473. DOI: 10.3760/cma.j.cn431274-20190401-00375
Abstract
Long non-coding RNAs (lncRNAs) are a kind of transcripts which are longer than 200nt and have not protein-coding ability due to the lack of an open reading frame. However, lncRNAs can be involved in tumorigenesis and progression in various ways at the transcriptional and post-transcriptional levels. Bladder cancer associated transcript 1 (BLACAT1) as a lncRNA located on human chromosome 1q32.1, is ectopic expression in various tumors (bladder cancer, gastric malignant tumor, lung carcinoma, et al) and can regulate tumor cell proliferation, anti-apoptosis, invasion and metastasis by different mechanisms leading to occurrence and development of tumors. In this review, we summarized current studies of the functions and mechanisms of BLACAT1 in malignant tumors.
Key words:
RNA, long noncoding; Bladder cancer associated transcript 1; Neoplasms; Therapeutic target; Review
Contributor Information
Xu Shuwan
Department of General Surgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China
Xia Haoming
Department of General Surgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China
Gao Zewei
Department of General Surgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China
Huang Rongju
Department of General Surgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China
Tang Enyu
Department of General Surgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China
Jiang Xingming
Department of General Surgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China
