Clinical application of combined urine markers detection in the diagnosis of patients with hypertension early renal damage
hong Liu, Lei Li, Ying Liu
Published 2016-09-15
Cite as Int J Urol Nephrol, 2016, 36(5): 744-746. DOI: 10.3760/cma.j.issn.1673-4416.2016.05.028
Abstract
ObjectivesTo explore the clinical significance and sensitivity of combined detection of the urine retinol conjugated protein(RBP), N-acetyl-β-D-amino grape glycosidase (NAG), urine micro proteinase inhibitor C(Cystatin C) and mALB in the diagnosis of patients with hypertension early renal damage.
MethodsFrom September 2014 to June 2015, 52 patients with essential hypertension as observational group and 30 healthy examination persons as control group were selected in our hospital.Urine RBP, Cystatin C, mALB and NAG levels were detected by enzyme-linked immunosorbent method and nitro phenol(PNP) colorimetric method.
ResultsThe urine RBP, Cystatin C, mALB and NAG levels of cases in observational group were higher than that of control group(P<0.001). The ROC curve and diagnostic test results showed that the area under the curve(AUC) of urine NAG, RBP was 0.952%, 0.932% and 95% CI was 0.911~0.993, 0.875~0.981 respectively(P<0.001), which had hjgher sensitivity compared with urine Cystatin C and mALB(P<0.001); Combined detection of urine RBP, NAG, Cystatin C and mALB had the AUC of 0.971 and 95% CI of 0.946~1.000(P<0.001).
ConclusionsCombined detection of urine markers would help monitor for patients with hypertension early renal damage and it has important clinical significance in the prevention of hypertensive nephropathy.
Key words:
Kidney Diseases; Hypertension
Contributor Information
hong Liu
Clinical Laboratory Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China
Lei Li
Ying Liu
