Original Article
Correlation study between benign prostatic fluid interleukin levels and prostate specific antigen in patients with benign prostatic hyperplasia complicated with prostatitis
Li Yongzhang, Yang Bingqi, Chen Wenbin, Zhou Yan, Wang Junhao, Han Jianpeng, Feng Jianyong
Published 2020-01-15
Cite as Int J Urol Nephrol, 2020,40(01): 49-52. DOI: 10.3760/cma.j.issn.1673-4416.2020.01.013
Abstract
ObjectiveTo study the correlation between benign prostatic fluid interleukin levels and prostate specific antigen(PSA) in patients with benign prostatic hyperplasia(BPH) complicated with prostatitis.
MethodsThe clinical data of 115 patients with BPH treated in our hospital from July 2014 to January 2018 were retrospectively analyzed. The situation of concurrent prostatitis, prostatic fluid interleukin levels, total PSA(TPSA) and free PSA(FPSA) and FPSA/TPSA were analyzed.
ResultsIn the 115 BPH patients, 76 patients had prostatitis, including 37 cases of grade I inflammation, 25 cases of II-grade inflammation, and 13 cases of grade III inflammation. The extent of inflammation and the degree of inflammation in the grade III-grade inflammation group were significantly higher than those in the I-grade and II-grade inflammation groups, and the differences were statistically significant(P<0.05). IL-2, IL-6, IL-8 and IL-10 in the III-grade inflammation group were significantly higher than those in the I-grade inflammation group and the II-grade inflammation group, and the differences were statistically significant(P<0.01). The TPSA and FPSA of the III-grade inflammation group were significantly higher than those of the I-grade inflammation group and the II-grade inflammation group, and the differences were statistically significant(P<0.01). There was no significant difference in FPSA/TPSA between the three groups(P>0.05). According to Pearson linear correlation analysis, there was no significant correlation between prostatic fluid IL-2 and PSA and FPSA in patients with BPH complicated with prostatitis(P>0.05). Prostatic fluid IL-6, IL-8, IL-10 were positively correlated with TPSA and FPSA(P<0.05).
ConclusionsBPH complicated with prostatitis is a risk factor for elevated PSA in patients, and the levels of IL-6, IL-8, IL-10 in prostatic fluid have a good correlation with PSA. Clinically, the diagnosis and treatment of BPH complicated with prostatitis can be performed according this, and improve clinical efficacy.
Key words:
Prostatic Hyperplasia; Interleukins; Prostate-Specific Antigen
Contributor Information
Li Yongzhang
Department of Urology, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang 050000, China
Yang Bingqi
Chen Wenbin
Zhou Yan
Wang Junhao
Han Jianpeng
Feng Jianyong
