Clinical Study
Impact of gender on the clinicopathological features of patients with primary IgA nephropathy
Wei Deng, Qian Zhou, Wenting Liu, Zhen Ai, Wei Chen, Xueqing Yu, Xiaojun Tan, Qiongqiong Yang
Published 2015-08-15
Cite as Chin J Nephrol, 2015, 31(8): 561-566. DOI: 10.3760/cma.j.issn.1001-7097.2015.08.001
Abstract
ObjectiveTo explore the impact of gender on the clinicopathological features of patients with primary IgA nephropathy (IgAN).
MethodsAll patients with IgAN who were biopsy-proven in The First Affiliated Hospital, Sun Yat-sen University from January 2006 to December 2011 were divided into two groups by gender: male group and female group. The clinical manifestations and pathological features of two groups were retrospectively investigated and compared.
ResultsA total of 1512 primary IgAN patients were enrolled in the study, and the ratio of male to female was 1:1.16, with a median age of 32(26, 39) years old at biopsy. Compared to female patients, male patients with IgAN exhibited more severe clinical manifestations including worse renal function, greater urinary protein excretion, and more frequent occurrence of hypertension, hypertriglyceridemia and hyperuricemia. Besides, male patients had worse histological lesions, including more severe segmental sclerosis, tubular-atrophy/interstitial fibrosis and interstitial infiltration. For female patients, hematuria, including gross and microscopic hematuria, was more frequent.
ConclusionMale patients with IgAN were with worse clinicopathological changes than those of female.
Key words:
Glomerulonephritis, IgA; Sex factors; Pathology, clinical
Contributor Information
Wei Deng
Department of Nephrology, Kaiping Central Hospital, Jiangmen City of Guangdong Province 529300, China
Qian Zhou
Wenting Liu
Zhen Ai
Wei Chen
Xueqing Yu
Xiaojun Tan
Qiongqiong Yang
