Clinical Study
Prevalence and risk factors of restless legs syndrome in peritoneal dialysis patients
Zhoubing Zhan, Yingying Xu, Yixian Huang, Peiran Yin, Ying Lu, Sheng Feng, Linsen Jiang, Zhi Wang, Kai Song, Huaying Shen, Weifeng Luo
Published 2019-01-15
Cite as Chin J Nephrol, 2019, 35(1): 36-42. DOI: 10.3760/cma.j.issn.1001-7097.2019.01.006
Abstract
ObjectiveTo investigate the prevalence of restless legs syndrome (RLS) in peritoneal dialysis patients and analyze the related risk factors.
MethodsThis study was a cross-sectional study. The patients receiving maintenance peritoneal dialysis from January 2017 to December 2017 in the Peritoneal Dialysis Center of the Second Hospital Affiliated to Soochow University were selected as the study subjects. RLS was screened for peritoneal dialysis patients by epidemiological field investigation based on the RLS diagnostic criteria of the International Restless Leg Syndrome Research Group in 2014. Clinical data and laboratory examinations of selected patients were collected and the differences of clinical indicators between RLS and non-RLS patients were compared. The risk factors related to RLS were analyzed by logistic regression.
ResultsSeventy-six cases of RLS were screened out from 396 PD patients. The prevalence of RLS was 19.2%. Compared with non-RLS group, RLS group patients had longer dialysis age, less 24 hours urine volume, and elevated blood intact Parathormone (iPTH) and alkaline phosphatase (AKP) (all P<0.05). There was no significant difference in primary disease ratio, sex, age, body mass index, blood pressure, hemoglobin, creatinine, urea nitrogen, uric acid, ferritin, serum iron, transferrin saturation, blood calcium, blood phosphorus, total cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, eGFR, Kt/V, Ccr between RLS and non-RLS group patients (all P>0.05). Multivariate logistic regression analysis showed that long dialysis age (OR=1.010, 95%CI 1.001-1.018, P=0.022) and high blood AKP (OR=1.005, 95%CI 1.001-1.010, P=0.021) were independent risk factors for RLS in peritoneal dialysis patients (both P<0.05).
ConclusionsThe prevalence of RLS is high in peritoneal dialysis patients. Long dialysis age and high blood AKP are independent risk factors for RLS.
Key words:
Peritoneal dialysis; Restless legs syndrome; Risk factors; Morbidity
Contributor Information
Zhoubing Zhan
Department of Nephrology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Yingying Xu
Department of Neurology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Yixian Huang
Department of Neurology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Peiran Yin
Department of Nephrology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Ying Lu
Department of Nephrology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Sheng Feng
Department of Nephrology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Linsen Jiang
Department of Nephrology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Zhi Wang
Department of Nephrology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Kai Song
Department of Nephrology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Huaying Shen
Department of Nephrology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
Weifeng Luo
Department of Neurology, the Second Hospital Affiliated to Soochow University, Suzhou 215004, China
