Clinical Study
Value of the baseline Geriatric Nutritional Risk Index in evaluating the prognosis of maintenance peritoneal dialysis patients
Li Afang, Dou Yanna, Wang Peipei, Zhang Bei, Luo Jing, Liu Dong, Cheng Genyang, Xiao Jing, Liu Zhangsuo, Zhao Zhanzheng
Published 2019-11-15
Cite as Chin J Nephrol, 2019, 35(11): 841-847. DOI: 10.3760/cma.j.issn.1001-7097.2019.11.007
Abstract
ObjectiveTo explore the value of baseline geriatric nutritional risk index (GNRI) in evaluating the prognosis of patients with end-stage renal disease (ESRD) who underwent peritoneal dialysis (PD).
MethodsThe clinical data of patients who underwent PD catheterization and started PD therapy at the First Affiliated Hospital of Zhengzhou University from January 1, 2013 to December 30, 2018 were collected retrospectively. The follow-up endpoint was death or hemodialysis. The follow-up deadline was March 1, 2019. The GNRI cut-off value was determined according to the ROC curve, and the patients were divided into GNRI≤90.5 group and GNRI>90.5 group. The differences of clinical data and laboratory tests were compared between the two groups. Kaplan-Meier survival curves were used to compare the difference in PD rate between the two groups during follow-up, and the factors that affecting patients PD withdrawal were analyzed by Cox regression.
ResultsThe GNRI cut-off value was determined to be 90.5 based on the ROC curve. Until the deadline for follow-up, the drop-out rate of GNRI≤90.5 group was significantly higher than the GNRI>90.5 group (35.88% vs 21.58%, P=0.003). Kaplan-Meier survival curves showed a higher rate of maintaining PD in the GNRI>90.5 group than that in GNRI≤90.5 group during follow-up (P=0.021). Cox univariate regression showed that male, GNRI and serum Alb were protective factors for PD patients, and Scr was a risk factor. After multiple factors correction, male and GNRI were also the protective factors for PD patients.
ConclusionAs an objective indicator of nutritional evaluation, baseline GNRI can be used as a prognostic indicator for PD patients.
Key words:
Peritoneal dialysis; Malnutrition; Prognosis; Geriatric nutritional risk index
Contributor Information
Li Afang
Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Institute of Nephrology, Zhengzhou University, Zhengzhou 450052, China
Dou Yanna
Wang Peipei
Zhang Bei
Luo Jing
Liu Dong
Cheng Genyang
Xiao Jing
Liu Zhangsuo
Zhao Zhanzheng