Objective To investigate the effect of humanistic nursing care and skill training for schizophrenia patients in rehabilitation.Methods 192 patients were randomly divided into research group and control group,96 for each group.The nursing theory of humanistic care,a three-rnonths skill training about life,occupation,social communication,self medication,symptom self-control,and one year follow-up after discharging were carried on the research group.The control group received conventional care.Satisfaction / comfort questionnaire,Social Disability Screening Scale (SDSS),Brief Psychiatric Rating Scale (BPRS),the mentally ill in rehabilitation outcome assessment scale (IPROS),medication adherence,relapse rates and readmission rates were used to assess the efficacy.Results After three months training,six months and 1 year after discharging from hospital,there were significant,differences in SDSS,BPRS,IPROS between the two groups.One year after discharging from hospital,there were significant differences in medication adherence,relapse,and readmission between the two groups.Upon discharging,there was significant differences in satisfaction /comfort level between the two groups (the research group:95.3 points; the control group:84.4 ; x2=4.06,P ＜ 0.05).Conclusions The research data shows that humanistic care conbining with comprehensive skill training can improve patients mental symptoms,reduce relapse rates and readmission rates,improve medication adherence,and has a positive end efficacious effect on patients comprehensive rehabilitation.