Objective To compare the clinical effects of target controlled intravenous anesthesia of propofol combined with fentanyl or remifentanil and isoflurane.Methods 96 ASA Ⅰ-Ⅱ elective surgical patients from June 2010 to February 2012 were randomly divided into three groups of 32 patients:propofol combined with fentanyl target-controlled group (group A),compound propofol remifentanil fentanyl target-controlled group (group B),anesthesia group (group C).Blood pressure,heart rate changes in anesthesia induction and maintenance were observed and recorded; spontaneous breathing recovery time,wake time,time to extubation,orientation recovery time were recorded; during 24 hours follow-up,nausea,vomiting and other adverse events were observed.Results The SBP,DBP,and the MAP,the H R induced by the lowest value in three groups had no significant difference (P＞0.05).Patients of the SBP ＜90 mmHg in Group A and Group B were significantly less than those of group C (P＜0.05).Intubation in Group A and group C were significantly higher than those in group B (P＜0.05).Recovery time of spontaneous breathing,wake time,time to extubation and orientation recovery time in three groups had no significant difference (P＞0.05).Incidence of adverse reactions in group A and group B was significantly lower than that of group C (P＜0.05).Conclusion Compared with isoflurane inhalation anesthesia,propofol combined with fentanyl or remifentanil target controlled intravenous anesthesia is more stable with less adverse reaction.