Objective To observe the short-term efficacy of Diane-35 in the treatment of adolescent patients with polycystic ovary syndrome.Methods The clinical data on 34 adolescent patients with polycystic ovary syndrome who had been treated in our hospital were reviewed.The efficacy of therapy with Diane-35 was analyzed.Results After treatment,symptoms of acne,amenorrhea,and oligomenorrhea were significantly improved (P＜0.05) but symptom of hirsutism did not imporve obviously (P＞0.05).The reproductive hormones (FSH,LH,E2,and T) were markedly decreased,as compared with the baselines (P＜0.05).Conclusions Diane-35 has better short-term efficacy in the treatment of menstrual disorder,acne and high androgen level in adolescent patients with polycystic ovary syndrome.