Objective To explore the efficacy of interventional treatment for diabetes complicated with lower limb arteriosclerosis obliterans.Methods 46 patients with diabetes complicated with lower limb arteriosclerosis obliterans were selected as study objects.All the patients were checked with CTA before the operation,then were treated interventionally,and were checked with DSA during the operation.The efficacies of different Fontatine types were compared after the treatment.The hemorrheology before the treatment was compared with that after the treatment.Results The efficacy was 100.0％ in Fontatine Ⅰ and Ⅱ,69.2％ in Fontatine Ⅲ,and 53.8％ in Fontatine Ⅳ.The efficacies of Fontatine Ⅰ and Ⅱ were significantly higher than that of Fontatine Ⅲ (x 2=4.062,P=0.044) and Fontatine Ⅳ (x 2＝6.769,P=0.009).Femoral artery systolic peak velocity was (76.53 ± 18.96) cm/s before the treatment and (68.18 ± 14.79) cm/s after the treatment,mean flow velocity (48.59 ± 12.26) cm/s and (44.10 ± 13.27) cm/s,blood flow (840.80 ± 51.13) ml/min and (796.21 ± 48.16) ml/min,pulsatility index (4.16 ± 0.59) and (4.83 ± 0.86),and flow index (0.63 ± 0.09) and (0.81 ± 0.20),with statistical differences (P ＜ 0.05).Conclusions Interventional treatment for Fontatine Ⅰ and Ⅱ diabetes complicated with lower limb arteriosclerosis obliterans has better efficacy than that for Fontatine Ⅲ and Ⅳ and can effectively improve the patient's hemorrheology.