Objective To study the clinical significance of PICCO for patients with severe brain injury complicated with hemorrhagic shock.Methods 48 patients with severe brain injury complicated with hemorrhagic shock were randomly divided into a treatment group and a control group.The control group took routine neurological treatment or surgical treatment and were infused fluid monitoring center venous pressure (CVP).PICCO was used in the treatment group.The effect of fluid resuscitation,GCS score,time to demachine,incidence of traumatic cerebral infarction,and mortality were compared between the 2 groups.Results One week after the treatment,the treatment group recovered better from hemorrhagic shock than the control group;GCS score was higher in the treatment group than in the control group; the treatment group de-machined earlier than the control group; the incidence of traumatic cerebral infarction and mortality were lower in the treatment group than in the control group; with statistical differences (P ＜ 0.05).Conclusions PICCO for patients with severe brain injury complicated with hemorrhagic shock can decrease the mortality and improve the prognosis.