To investigate the detection rate of breast nodules and lesions by combining physical examination, color Doppler ultrasound, X-ray mammography, magnetic resonance imaging, and serum molecular markers.

The medical records of women undergoing body examination at our hospital were analyzed. They were examined by interrogation, breast physical examination, and color Doppler ultrasonography (B ultrasound, BUS). If breast nodules were found, methods such as mammography (MG) and nuclear magnetic resonance imaging (MRI) were used for further comprehensive examination. Each breast lesion imaging morphological features, including lesion shape, lesion edge, number of lesions, was analyzed; and the MR enhancement within the lesions, early strengthened rate, and the peak value and apparent diffusion coefficient after injection of contrast agent were analyzed. The breast imaging reporting and data system (BI-RADS) was used to score and in classification diagnosis. Serum molecular markers, such as carbohydrate antigen (CA153) and thymidine kinase (TK1), were detected in some patients.

A total of 10 000 female patients were examined. 8 113 cases were examined by breast color Doppler ultrasound, including 5 324 cases of ultrasound nodule image (cystic, solid, cystic, BIRAD classification type 2-4b). 3 278 cases was classified as type 2; 1 833 type 3, and needed examination of mammography; 213 type 4 or higher types, and needed mammography, MRI examination, and serum molecular markers CA153 and TK1. Eight patients suspected with breast cancer were refered to breast surgery, biopsy, and (or) surgical resection.

Combining physical examination, color Doppler ultrasound, mammography, magnetic resonance imaging, and serum molecular markers can improve the detection rate of breast nodules and lesions.

Breast lesions; Health management; Physical examination; Color Doppler ultrasound; X-ray mammography; Magnetic resonance imaging; Breast cancer