Clinical Research
Compound glycyrrhizin injection combined with ademetionine in treatment of infantile cytomegalovirus hepatitis
Fang Wenbin, Yuan Yanping, Liu Kai
Published 2018-12-15
Cite as IMHGN, 2018,24(24): 3810-3813. DOI: 10.3760/cma.j.issn.1007-1245.2018.24.028
Abstract
ObjectivesTo observe the clinical efficacy of compound glycyrrhizin injection combined with ademetionine in the treatment of infantile cytomegalovirus (CMV) hepatitis.
MethodsA total of 68 infants with cytomegalovirus hepatitis who met the inclusion criteria and were treated at our hospital from January, 2017 to January, 2018 were randomly divided into a control group and a study group, 34 cases for each group. The control group were treated with ganciclovir, and the study group with ganciclovir, compound glycyrrhizin injection, and ademetionine. The 2 groups were treated for 14 days. The liver and spleen size, serum total bilirubin(STB), alanine aminotransferase(ALT), and aspartate aminotransferase(AST), serum CMV-IgM antibody, and CMV-DNA positive rate were observed and recorded before and after the treatment.
ResultsThe total effective rate was 97.1% (33/34) in the study group, and 82.4% (28/34) in the control group, with a statistical difference ( P<0.05). After the treatment, the liver size and the spleen size decreased more in the study group than in the control group [(2.02±0.25) cm vs. (1.09±0.34) cm and (1.34±0.23) cm vs. (0.75±0.33) cm, both P<0.05]. The levels of STB, ALT, and AST were lower after than before the treatment in both groups, with statistical differences (all P<0.05). After the treatment, the levels of STB, ALT, and AST and the positive rates of CMV-IgM and CMV-DNA were significantly lower in the study group than in the control group [ (67.5±34.8) U/L vs. (125.3±41.6) U/L, (73.9±22.7) U/L vs. (135.7±25.8) U/L, (45.1±21.6) mmol/L vs. (96.8±30.8) mmol/L, 14.7% vs. 67.6%, and 17.6% vs. 64.7%], with statistical differences (all P<0.05). There was no statistical difference in the incidence of clinical adverse reactions between the 2 groups (P>0.05).
ConclusionsCompound glycyrrhizin injection combined with ademetionine for infantile cytomegalovirus hepatitis can significantly reduce their symptoms of hepatosplenomegaly, levels of STB, ALT, and AST, and positive rates of blood CMV-IgM antibody and CMV-DNA, and improve the treatment efficacy.
Key words:
Infants; Hepatitis; Cytomegalovirus; Ademetionine; Compound glycyrrhizin injection
Contributor Information
Fang Wenbin
Department of Pediatrics, Shanxian Central Hospital, Heze 274300, China
Yuan Yanping
Liu Kai
