New Perspective
Serum concentrations of sodium valproate by nasal versus oral administration
Tang Lian, Zhong Yanan, Zhuang Zhiwei, Shen Yi, Lu Jian, Xu Xiaowen, Yang Chen4, Shang Erning1, Xue Sudong1
Published 2019-05-01
Cite as IMHGN, 2019,25(9): 1361-1364. DOI: 10.3760/cma.j.issn.1007-1245.2019.09.005
Abstract
ObjectiveTo analyze the differences of serum concentrations of sodium valproate by nasogastric and oral administration, and the correlation between serum concentration and dosage.
MethodsPatients taken single-agent sodium valproate tablets were collected retrospectively from January 2016 to December 2017 from The Affiliated Suzhou Hospital of Nanjing Medical University. The patients were divided into a nasogastric administration group and an oral administration group. The basic information as well as the dosage, administration method, and the serum concentration of sodium valproate were recorded.
Results258 cases were included, with 136 in the nasogastric group and 122 in the oral group. The linear correlation analysis indicated that there was a positive correlation between the serum concentration and daily dose of sodium valproate (The nasogastric group: R=0.617, P<0.001; the oral group: R=0.435, P<0.001). The serum concentrations at the daily doses of 600 mg and 1 200 mg were significantly lower in the nasogastric group than in the oral group [(31.0±10.4) μg/ml vs. (44.2±13.9) μg/ml, P<0.001; (57.5±22.5) μg/ml vs. (62.0±9.8) μg/ml, P=0.003].
ConclusionThere is a positive correlation between the serum concentration and daily dose of sodium valproate. At the same dosage, the serum concentration of sodium valproate was significantly lower in the nasogastric group than in the oral group.
Key words:
Sodium valproate; Serum concentration; Nasogastric administration; Oral administration
Contributor Information
Tang Lian
Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
Zhong Yanan
College of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
Zhuang Zhiwei
Intensive Care Unit, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
Shen Yi
Intensive Care Unit, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
Lu Jian
Intensive Care Unit, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
Xu Xiaowen
Intensive Care Unit, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
Yang Chen4
Medical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
Shang Erning1
Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
Xue Sudong1
Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China
