To observe the effect of early continuous renal replacement therapy (CRRT) on the prognosis of patients treated by extracorporeal membrane oxygenation (ECMO).

46 patients with acute kidney injury (AKI) taking ECMO support in our hospital from January, 2015 to December, 2017 were randomly divided into an early treatment group and a conventional treatment group. According to the stage of renal injury, the CRRT treatment intervention time was determined. The basic data, ECMO auxiliary time, mechanical ventilation time, renal replacement time, ICU treatment time, renal function outcomes were observed and statistically analyzed.

There were no statistical differences in the basic data between the two groups. The ECMO-assisted time, mechanical ventilation support time, renal replacement time, and ICU treatment time were shorter and the number of fluid overload cases was lower in the early treatment group than in the conventional treatment group.

The use of renal replacement therapy in the early stage of acute kidney injury in critically ill patients taking extracorporeal membrane oxygenation support can reduce the ECMO-assisted time, mechanical ventilation time, renal replacement time, and ICU treatment time, as well as the incidence of fluid overload and treatment cost, and improve the prognosis.

Extracorporeal membrane oxygenation; Acute renal injury; Continuous renal replacement therapy; Organization for Improvement of Global Renal Disease Prognosis