Treatises
Serum levels of IL-17 and IL-22 in evaluation of clinical stage and prognosis of patients with lung cancer
Liu Dan, Lin Haibiao, Xing Shan, Chen Lin, Luo Fudong, Lin Li, Shi Wen, Lin Fujia, Huang Xianzhang
Published 2019-08-15
Cite as IMHGN, 2019,25(16): 2712-2714. DOI: 10.3760/cma.j.issn.1007-1245.2019.16.030
Abstract
ObjectiveTo explore the role of T helper cell 17 (Th17) associated cytokines in lung cancer tumors by evaluating the correlation of serum levels of interleukin-17 (IL-17) and interleukin-22 (IL-22) with clinical indicators and prognosis in patients with lung cancer.
MethodsThe serum levels of IL-17 and IL-22 in 195 patients with lung cancer, collected from Cancer Center, Sun Yat-sen University from December, 2008 to November, 2010 were detected by enzyme-linked immunosorbent assay (ELISA). SPSS 17.0 were used to statistically analyze of the levels of IL-17 and IL-22, clinical indicators, and prognosis.
ResultsThe level of IL-17 was significantly increased with the disease progression, and the statistical differences were also found in tumor size and lymph node metastasis (all P<0.05). Multivariate analysis showed that age, clinical stage, and serum IL-17 level were independent risk factors for the prognosis of the lung cancer patients.
ConclusionTh17-associated cytokines may involve in tumor progression and lymph node metastasis in lung cancer.
Key words:
Lung cancer; IL-17; IL-22
Contributor Information
Liu Dan
Department of Clinical Laboratory, Second Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510105, China
Lin Haibiao
Department of Clinical Laboratory, Second Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510105, China
Xing Shan
Department of Clinical Laboratory, Cancer Center, Sun Yat-sen University, Guangzhou 510105, China
Chen Lin
Department of Clinical Laboratory, Second Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510105, China
Luo Fudong
Department of Clinical Laboratory, Second Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510105, China
Lin Li
Department of Clinical Laboratory, Second Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510105, China
Shi Wen
Department of Clinical Laboratory, Second Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510105, China
Lin Fujia
Department of Clinical Laboratory, Second Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510105, China
Huang Xianzhang
Department of Clinical Laboratory, Second Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510105, China
