To investigate the effect of early intermittent veno-venous hemofiltration combined with mechanical ventilation for patients with severe thoracic trauma complicated with traumatic wet lung.

A total of 33 patients with severe thoracic trauma complicated with traumatic wet lung admitted to our hospital from October, 2014 to July, 2018 were selected, and were divided into a hemofiltration group (19 cases) and a control group (14 cases). The control group received conventional comprehensive treatment. On the basis of routine comprehensive treatment, the hemofiltration group received early intermittent veno-venous hemofiltration and mechanical ventilation. The records of these two groups’ vital signs, hemodynamic parameters, oxygenation index, APACHE Ⅱ rating, etc. were collected.

After the treatment, the extravascular lung water index (EVLWI) and APACHE Ⅱ score were significantly lower in the hemofiltration group than in the control group [(10.9±3.0) ml/kg vs. (13.9±5.1) ml/kg and (20.2±3.1) vs. (22.9±4.3), both P<0.05). The average mechanical ventilation time and the average ICU time were shorter in the hemofiltration group than in the control group [(12.3±4.4) d vs. (9.2±3.1) d and (13.6±9.8) d vs. (11.2±6.4) d, both P<0.05).

Early intermittent hemofiltration combined with mechanical ventilation could significantly improve the pulmonary function and prognosis and shorten the duration of mechanical ventilation patients with severe thoracic trauma complicated with traumatic wet lung.

Veno-venous Hemofiltration; Severe thoracic trauma; Traumatic wet lung; Mechanical ventilation