Viral Hepatitis
Research on the causes of death associated with combined effects of HBV and HCV infection in patients with acquired immunodeficiency syndrome
Guo Pengle, Cai Weiping, Chen Xiejie, He Haolan, Hu Fengyu, Tang Xiaoping, Li Linghua
Published 2018-07-20
Cite as Chin J Hepatol, 2018,26(7): 495-498. DOI: 10.3760/cma.j.issn.1007-3418.2018.07.003
Abstract
ObjectiveTo investigate the combined effects of hepatitis B virus and hepatitis C virus (HBV/HCV) infection on the cause of death in patients with acquired immunodeficiency syndrome (AIDS).
MethodsThe causes of death of 111 cases of AIDS with HBV/HCV (combined infection group) and 210 AIDS patients (single infection group) admitted to our hospital from 2012 to 2016 data were compared using chi-square test.
ResultsThere was no statistically significant difference in gender composition and age in the combined infection groups (P > 0.05). The main causes of death in the combined infection group were severe pneumonia (44.1%), end-stage liver disease (18.9%), and central nervous system infection (14.4%). The main causes of death in the single infection group were severe pneumonia (47.6%) and central nervous system infection (14.3%) and tumor (13.3%). There was no case of end-stage liver disease. The ratio of end-stage liver disease in the former group was significantly higher than that in the latter group (χ2 = 42.511, P < 0.001). The main cause of death in 12 HIV/HBV/HCV triple-infected patients was end-stage liver disease, accounting for 41.7%, which was significantly higher than 18.9% of end-stage liver disease in HIV/HBV or HIV/HCV dual infection (99 cases). And the difference was statistically significant (χ2 = 4.539, P = 0.033); however, the ratio of end-stage liver disease in 50 HIV/HBV co-infected patients and 49 HIV/HCV co-infected patients was 16.0% vs. 16.3%, respectively, and the difference was not statistically significant (χ2 = 0.002, P = 0.965). In the co-infected group, 36 patients had CD4+ cell counts >100/μl, the primary cause of death was end-stage liver disease, accounting for 38.2%. 75 patients with CD4+ ≤ 100/μl died due to end-stage liver disease, accounting for 9.3% and the difference was statistically significant (χ2 = 13.852, P < 0.05).
ConclusionEnd-stage liver disease is the main cause of death in patients with AIDS combined with HBV or HCV, especially triplet infection and CD4+ cell count > 100/μl. An early diagnosis and treatment of HBV or HCV infection should commence as soon as possible.
Key words:
Acquired immunedeficiency syndrome; End-stage liver diseases; Cause of death; Human immunodeficiency virus; Hepatitis C virus; Hepatitis B virus
Contributor Information
Guo Pengle
Department of Infectious Diseases, Guangzhou Eighth People’s Hospital, Guangzhou 510060, China
Cai Weiping
Chen Xiejie
He Haolan
Hu Fengyu
Tang Xiaoping
Li Linghua
