Review
Role and potential value of circular RNAs in the occurrence of primary hepatic cancer
Zhenluo Jiang, Lili Shen, Yaoren Hu, Junming Guo, Liyun Fu
Published 2019-02-20
Cite as Chin J Hepatol, 2019, 27(2): 157-160. DOI: 10.3760/cma.j.issn.1007-3418.2019.02.018
Abstract
Circular RNA is a class of non-coding RNAs, which are covalently closed and circular at both ends, showing dissimilar characteristics from linear RNA. Several studies have shown that circular RNAs play an important role in the occurrence and development of primary hepatic cancer. By combining with the latest research progress of this field at home and abroad, we summarized the mechanism regulating the occurrence and development of liver cancer, abnormal expression, and as potential molecular markers for disease diagnosis and treatment.
Key words:
Carcinoma, hepatocellular; Circular RNA; MicroRNA; Biomarker
Contributor Information
Zhenluo Jiang
Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China
Department of Hepatology, Ningbo No.2 Hospital, Ningbo 315020, China
Lili Shen
Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China
Department of Hepatology, Ningbo No.2 Hospital, Ningbo 315020, China
Yaoren Hu
Department of Hepatology, Ningbo No.2 Hospital, Ningbo 315020, China
Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo 315020, China
Junming Guo
Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China
Liyun Fu
Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China
Department of Hepatology, Ningbo No.2 Hospital, Ningbo 315020, China
Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo 315020, China
