A retrospective study of ocular manifestations and aquaporin 4 antibody concentrations in 132 patients with neuromyelitis optica
Wenting Liu, Jiaying Zhang, Chao Quan, Wen Ye, Xiangjun Chen, Zhaozeng Lu
Published 2019-05-25
Cite as Chin J Ocul Fundus Dis, 2019, 35(3): 246-250. DOI: 10.3760/cma.j.issn.1005-1015.2019.03.007
Abstract
ObjectiveTo observe the ocular manifestations and the titer of aquaporin 4 antibody(AQP-4) in NMO patients, and to evaluate the BCVA prognosis in patients with different titers of AQP-4Ab.
MethodsA retrospective case study. From September 2009 to March 2014, 132 NMO patients diagnosed in Department of Neurology and Ophthalmology in Huashan Hospital of Fudan University were included in the study. Among the patients, 74 patients (56.06%) were involved in optic nerve for the first time, among which 63 patients (47.72%) were involved in optic nerve alone, and 11 patients (8.33%) were involved in optic nerve and spinal cord at the same time. The recurrence rate was 62.88% (twice or more). All patients underwent BCVA, slit lamp microscope, fundus examination, thyroid function, sex hormones, and serum AQP-4Ab detection. BCVA was recorded at admission and before discharge from hospital, and worse BCVA was recorded in binocular patients. The BCVA of patients with different titers of AQP-4Ab were analyzed comparatively.
ResultsAmong the 74 patients with optic nerve involved in the first onset, 50 patients with BCVA<0.1 at the initial diagnosis(67.57%); AQP-4Ab positive was found in 56 patients, which including 13, 9 and 34 patients of AQP-4Ab titer 5 - 60, 61 - 100 and >100 RSRU/ml. After 2 weeks of treatment, BCVA improved in 40 patients (71.42%), including 11 (84.62%), 6 (66.67%) and 23 (67.64%) of AQP-4Ab titer 5 - 60, 61 - 100 and > 100 RSRU/ml. Among 132 patients, 98 patients (74.24%) were AQP-4Ab positive. There were 73 patients (55.30%) with abnormal immune rheumatoid index.
ConclusionsThe optic nerve is involved in 56.06% patients with NMO for the first time, and 67.57% of the patients had poor vision with BCVA<0.1. BCVA prognosis is better in patients with serum AQP-4Ab titer of 5 - 60 RSRU/ml.
Key words:
Neuromyelitis optica; Vision; Aquaporin 4
Contributor Information
Wenting Liu
Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai 200030, China (Liu Wenting is working on the Department of Ophthalmology, Huadong Hospital of Fudan University, Shanghai 200030, China)
Jiaying Zhang
Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai 200030, China (Zhang Jiaying is working on the Department of Ophthalmology, West China Hospital, Sichun University, Chengdu 610041, China)
Chao Quan
Department of Neurology, Huashan Hospital of Fudan University, Shanghai 200030, China
Wen Ye
Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai 200030, China
Xiangjun Chen
Department of Neurology, Huashan Hospital of Fudan University, Shanghai 200030, China
Zhaozeng Lu
Department of Ophthalmology, Huashan Hospital of Fudan University, Shanghai 200030, China
