Original Article
Therapeutic Effect and Prognostic Evaluation of Atomize Inhaling Glucocorticoid, Terbutaline and Beclomethasone Ipratropine on Bronchiolitis
LIU Jie-ming, ZHOU Ye-di, LIU Xiao-yan, LIU Li-qun, LIU Dong-hai, YI Zhu-wen
Published 2008-11-20
Cite as J Appl Clin Pediatr, 2008, 23(22): 1778-1779,1787. DOI: 10.3760/cma.j.issn.2095-428X.2008.22.125
Abstract
ObjectiveTo observe the therapeutic effect of atomize inhaling glucocorticoid, terbutaline and beclomethasone ipratropine for pedo-bron-chiolitis and explore the prognostic influence of glucocorticoid.
MethodsOne hundred and eight patients with pedo-bronchiolitis were divided into 3 groups randomly. The patients in group 1 were treated 12 weeks with pulmicort, ipratropine and terbutaline; the patients in group 2 were treated 7 days with pulmicort and terbutaline; and the control group were treated 7 days with terbutaline only. The disappearance of the clinical symptoms and the during hospital stay were observed and clinical therapeutic effects in 3 groups were evaluated. And the number and attack rate of gasping illness was followed up 1 year after discontinuation of the treatment.
ResultsThe duration of the symptoms including cough wheezing rale and the hospital day in treatment group were superior to those in the control group (Pa<0.05). The treatment group in clinical remission rate was better, and withdraw treatment to 1 year in asthmatic disease, the prevalence rate in treatment group 1 decreased significantly (P<0.05), the prevalence rate in treatment group 2 was slightly lower than that in the control group (P>0.05).
ConclusionsThe therapeutic effect of atomize inhaling glucocorticoid, terbutaline a for pedo-bronchiolitis is sure, using atomize inhaling glucocorticoid, terbutaline and beclomethasone ipratropine to reduce the acute symptoms of children with bronchiolitis is with the more obvious advantages. It can reduce the risk to develop asthma with inhaled glucocorticoids for 12 weeks as an early intervention.
Key words:
bronchiolitis; glucocorticoid; ipratropine; terbutaline
Contributor Information
LIU Jie-ming
Department of Pediatrics, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
ZHOU Ye-di
Clinical Medicine, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan Province, China
LIU Xiao-yan
Department of Pediatrics, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
LIU Li-qun
Department of Pediatrics, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
LIU Dong-hai
Department of Pediatrics, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
YI Zhu-wen
Department of Pediatrics, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China