To investigate long term efficacy of anticoagulation combined with catheter-directed thrombolysis(CDT) in the treatment of acute iliofemoral venous thrombosis.

The clinical data of 75 patients with iliofemoral venous thrombosis in the department of vascular surgery, the second affiliated hospital of Guangzhou medical university from February 2012 to July 2016 were analyzed retrospectively. They were divided into single anticoagulation group(A), CDT combined with anticoagulation group(B). Follow-up studies were performed to inquire about patient symptoms, check the status of affected extremities and examine venous patency with venous ultrasonography or anterograde venous radiography. The incidence rate of post-thrombotic syndrome(PTS) was evaluated with the Villalta score and the quality of life was evaluated with CIVIQ-2 questionnaire.

At the follow-up of 12 and 24 months, the venous potency rates were (0.58±0.25)%, (0.62±0.25)% in groups A, and (0.93±0.13)%, (0.94±0.13)% in group B, respectively. The differences were significant between group A and B(P<0.05) at both 12-and 24-month after treatment. The Villalta scores were(2.47±1.19) vs(2.00±1.28) in group A(P>0.05) and (2.15±1.26) vs (1.78±1.33) in group B(P>0.05) at 12-, 24-manth during follow-up time, respectively. The incidence of PTS was 8.8% in group A, while 4.9% in group B at 12, 24 months during followed-up. At the follow-up of 12 and 24 months, CIVIQ-2 scores were (21.82±1.96) vs(20.95±1.20) in group A(P<0.05), while (21.35±1.92) vs (20.73±1.10) in group B(P>0.05), respetively.

The therapy of CDT has significant role in improving the vein patency in patients with DVT.Compared with single anticoagulation, combination of CDT and anticoagulation may reduce the risk of PTS and improve quality of life in the long-term clinical effect.

Acute iliofemoral venous thrombosis; Catheter-directed thrombolysis; Long-term efficacy