To explore the potential value of basal serum anti-Mülerian hormone (AMH) concentration in predicting ovarian response and pregnancy outcomes in follicular-phase long-acting gonadotropin releasing hormone (GnRH) agonist long protocol.

This study is an aggregated cohort study based on electronic medical records and a total number of 4 075 patients were recruited in this retrospective study. These patients were divided into three groups (low, normal and high response) according to the ovarian response and were divided into two groups (pregnancy and non-pregnancy) according to pregnancy outcomes. The logistic regression analysis and receiver operating characteristic curve (ROC) were used to compare the predictive value of AMH on ovarian response and pregnancy outcomes.

Basal AMH was the most effective factor for predicting ovarian response. The area under the receiver operating characteristic curve (AUC) analysis of AMH for low and high ovarian response prediction was 0.853 and 0.764, respectively. The cut-off point of AMH for predicting low and high ovarian response is 1 μg/L and 2.75 μg/L, respectively. AMH has a low predictive value for clinical pregnancy outcomes.

Basal AMH is the most powerful predicting factor for ovarian response, especially for low ovarian response, but not a significant predicting factor for pregnancy outcomes.

anti-Mülerian hormone (AMH); Follicular long-acting gonadotropin releasing hormone (GnRH) agonist long protocol; Ovarian response; Pregnancy outcomes