Review
Research progress of maternal-fetal interface microenvironment in recurrent abortion
Feng Dan, Shi Wenjing, Yan Qin, Sun Chunqing, Bi Xingyu, Zhang Xiuping, Xu Suming, Wang Yaoqin, Wu Xueqing
Published 2022-05-25
Cite as Chin J Reprod Contracep, 2022, 42(5): 518-523. DOI: 10.3760/cma.j.cn101441-20211008-00448
Abstract
Recurrent spontaneous abortion (RSA) is a common adverse pregnancy outcome in women of childbearing age and its etiology is complex and still not clear. The maternal-fetal interface microenvironment plays a key role in maintaining pregnancy. There are trophoblast cells, decidual stromal cells and immune cells in the maternal-fetal interface microenvironment. The abnormal number or function of these cells may induce changes in the microenvironment of maternal-fetal interface, such as spiral artery remodeling disorder and abnormal decidualization, which may lead to RSA. This review discusses the role and mechanism of these three main cells in RSA.
Key words:
Recurrent spontaneous abortion; Maternal-fetal interface; Immune cells; Trophoblast cell; Decidual stromal cells
Contributor Information
Feng Dan
Shanxi Medical University, Taiyuan 030001, China
Shi Wenjing
Shanxi Medical University, Taiyuan 030001, China
Yan Qin
Shanxi Medical University, Taiyuan 030001, China
Sun Chunqing
Shanxi Medical University, Taiyuan 030001, China
Bi Xingyu
Center of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan 030013, China
Zhang Xiuping
Center of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan 030013, China
Xu Suming
Center of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan 030013, China
Wang Yaoqin
Center of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan 030013, China
Wu Xueqing
Center of Reproductive Medicine, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan 030013, China
