Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder of females. The abnormality of glucose and lipid metabolism is closely related to reproductive dysfunction. The ovary is an organ with active energy metabolism. The proliferation of granulosa cells, the maturation and ovulation of oocytes are all energy-consuming processes and require sufficient energy supply. Sugars and lipids are decomposed in granulosa cells and provide energy for oocyte development through gap junctions. Abnormal glucose and lipid metabolism in PCOS patients is manifested in the changes of signal molecules and cytokines in ovarian granulosa cells and follicular fluid, and the changes of metabolites in follicular fluid, which affect follicular development and oocyte quality. This article reviewed the characteristics of glucose and lipid metabolism and the relationship between cytokines associated with glucose and lipid metabolism and the development and quality of follicular in PCOS patients, contributing to provide reference for clinic.

Polycystic ovary syndrome; Glycolipids; Metabolism; Cell factor; Oocytes growth/development