Clinical Study
Effect of maternal depression in assisted reproductive techonology on offspring's premature delivery and low birth weight
Zhou Junlan, Peng Xiaoqing, Liang Chunmei, Lu Zhimin, Jiang Tingting, Cao Yunxia
Published 2022-08-25
Cite as Chin J Reprod Contracep, 2022, 42(8): 814-819. DOI: 10.3760/cma.j.cn101441-20210420-00179
Abstract
ObjectiveTo evaluate the relationship between antenatal depression in mothers who received assisted reproductive techonology (ART) and premature birth and low birth weight.
MethodsIn this retrospective cohort study, 376 infertile women who successfully delivered single-child were recruited at the Reproductive Center, Department of Obstetrics and Gynecology of the First Affiliated Hospital of Anhui Medical University from May 2017 to December 2020. Binary logistic regression analysis model was used to analyze the association between pre-pregnancy depression, depression in the first, second and third trimesters and new onset depression during pregnancy with preterm delivery and low birth weight.
ResultsThe detection rates of depression before pregnancy, in the first, second and third trimesters of pregnancy were 20.0% (75/376), 23.0% (83/363), 11.2% (41/366), 8.8% (31/354), respectively. There was no statistically significant association between depression in the pre-pregnancy, the first trimester and the second trimester and preterm delivery (all P>0.05). Depression in the third trimester (RR=2.18, 95% CI=1.02-4.65, P=0.040) and new onset depression during pregnancy (RR=2.03, 95% CI=1.01-4.05, P=0.046) were positively correlated with preterm delivery. The associations between pre-pregnancy depression, depression in the first, second and third trimesters, and new onset depression and low birth weight were not statistically significant (all P>0.05).
ConclusionAntenatal depression in the third trimester and new onset depression during pregnancy may be important risk factors for premature delivery, but there is no significant association between antenatal depression and low birth weight.
Key words:
Reproductive technology, assisted; Antenatal depression; Premature delivery; Low birth weight
Contributor Information
Zhou Junlan
School of Pharmacy, Anhui Medical University, Hefei 230032, China
Peng Xiaoqing
Reproductive Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Liang Chunmei
Reproductive Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Lu Zhimin
Reproductive Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
Jiang Tingting
Department of Hygiene Analysis and Detection, School of Public Health, Anhui Medical University, Hefei 230032, China
Cao Yunxia
Reproductive Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
