Review
Advances in genetics of oocyte maturation arrest, fertilization failure and early embryo arrest
Liu Liting, Gao Yang, He Xiaojin
Published 2022-12-25
Cite as Chin J Reprod Contracep, 2022, 42(12): 1297-1304. DOI: 10.3760/cma.j.cn101441-20211016-00464
Abstract
Oocyte maturation arrest, fertilization failure and early embryonic arrest are the focus of modern reproductive medicine. Oogenesis is a very complex process. Oocyte maturation arrest and early embryonic arrest are caused by many genetic factors. It has been 30 years since the first case of human oocyte maturation arrest was reported. Until recent years, the pathogenic genes and molecular mechanisms of oocyte maturation arrest have been extensively studied in human and mouse models. Significant progress has been made in the study of fertilization failure or embryo development arrest. This article reviews the recent genetic studies of oocyte maturation arrest, fertilization failure and early embryonic arrest.
Key words:
Oocytes; Infertility, female; Genetics; Oocyte maturation arrest; Embryo development
Contributor Information
Liu Liting
Reproductive Medicine Center of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Anhui Province Key Laboratory of Reproductive Health and Genetics, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei 230032, China
Gao Yang
Reproductive Medicine Center of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Anhui Province Key Laboratory of Reproductive Health and Genetics, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei 230032, China
He Xiaojin
Reproductive Medicine Center of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Anhui Province Key Laboratory of Reproductive Health and Genetics, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei 230032, China
