Fertility Preservation Column
Clinical practice of fertility preservation in young unmarried breast cancer patients
Guo Mengxi, Chen Xiaojun, Wu Dandan, Wang Min, Wang Li, Li Wen
Published 2023-02-25
Cite as Chin J Reprod Contracep, 2023, 43(2): 129-133. DOI: 10.3760/cma.j.cn101441-20220626-00276
Abstract
ObjectiveTo analyze the clinical practice of fertility preservation in unmarried young female breast cancer patients in China.
MethodsThis was a retrospective study of 13 unmarried female patients who underwent fertility preservation due to breast cancer in the Reproductive Medicine Center of International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine from January 2019 to December 2020.
ResultsThe age of the patients was (31.00±3.98) years old. Nine patients used follicular phase letrozole (LE)+gonadotropin (Gn) ovarian stimulation protocol, 3 patients used luteal phase LE+Gn stimulation protocol, and 1 patient used natural cycle protocol. Eleven patients completed the fertility preservation procedure, with a total Gn used dosage of (1 865.91±501.03) U, estradiol level at trigger of (1 223.85±709.75) ng/L, and 9.91±4.41 frozen oocytes. All of them used vitrification freezing.
ConclusionOocyte vitrification frozen after LE+Gn ovarian stimulation is the preferred solution in young unmarried breast cancer patients for fertility preservation. However, promoting the awareness of fertility preservation, improving communication between clinical departments, and increasing clinical practice still need to be promoted.
Key words:
Breast neoplasms; Fertility preservation; Oocyte; Vitrification; Single person
Contributor Information
Guo Mengxi
Reproductive Medical Center, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
Chen Xiaojun
Reproductive Medical Center, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
Wu Dandan
Reproductive Medical Center, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
Wang Min
Reproductive Medical Center, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
Wang Li
Reproductive Medical Center, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
Li Wen
Reproductive Medical Center, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
