ART Offspring Safety Disorder
Perinatal outcomes of singleton live birth resulting from human assisted reproductive technology: a retrospective propensity score matching cohort study
Zheng Wei, Ren Bingnan, Yang Chen, Ran Shiyu, Wu Huan, Wang Rui, Dou Shanshan, Shen Ran, Han Jingyi, Li Peixin, Guan Yichun
Published 2023-06-25
Cite as Chin J Reprod Contracep, 2023, 43(6): 559-565. DOI: 10.3760/cma.j.cn101441-20221130-00531
Abstract
ObjectiveTo compare perinatal outcomes of singleton live births between human assisted reproductive technology (ART) and spontaneously conceived (SC).
MethodsThis study was a retrospective cohort study, collecting data on patients who delivered and obtained singleton live birth in the Obstetrics Department of the Third Affiliated Hospital of Zhengzhou University between 2008 and 2019. A total of 1 727 ART patients were included in this study, and 5 181 SC patients who delivered during the same day were matched at a ratio of 1∶3. After matching according to delivery time, the baseline data of the two groups were matched using 1∶1 propensity score matching (PSM), and finally 1 439 patients were included in the ART and SC groups, respectively. The primary outcome measure was the healthy baby rate, and the secondary outcome measures were perinatal outcomes such as the incidences of hypertensive disorders of pregnancy, gestational diabetes and preterm delivery rate.
ResultsAfter PSM, healthy baby rate was lower in the ART group compared with the SC group [77.28% (1 112/1 439) vs. 70.67% (1 017/1 439), P<0.001]. Pregnancy complications, including the incidence of gestational diabetes, intrahepatic cholestasis syndrome during pregnancy, abnormal thyroid function during pregnancy, oligohydramnios, placenta previa, cesarean delivery, and placental efficiency, were statistically different between the two groups (all P<0.05). The neonatal outcomes, including gestational age, preterm delivery rate, very preterm delivery rate, incidence of small for gestation age and neonatal intensive care unit admission rate were statistically different between the two groups (all P<0.05). The results of multivariate logistic regression analysis showed that ART and pregnancy complications were risk factors for healthy baby (OR=0.81, 95% CI:0.67-0.97, P=0.020), however, placental efficiency was a protective factor for healthy baby (OR=1.73, 95% CI:1.59-1.88, P<0.001).
ConclusionPerinatal outcomes were safer in the SC group than in the ART group.
Key words:
Reproductive techniques, assisted; Spontaneously conceived; Singleton live births; Perinatal outcomes
Contributor Information
Zheng Wei
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Ren Bingnan
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Yang Chen
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Ran Shiyu
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Wu Huan
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Wang Rui
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Dou Shanshan
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Shen Ran
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Han Jingyi
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Li Peixin
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Guan Yichun
Reproductive Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
