Clinical Research
The analysis of clinical and pathological factors related to surgical metastatic anorectal malignant melanoma
Liu Xin, Qiao Jun, Zhang Rui, Si Lu, Mao Lili, Liu Yanlong, Chi Zhaocheng, Ding Peirong, Chen Yu, Liu Fang
Published 2022-06-30
Cite as Chin J Metastatic Cancer, 2022, 05(2): 122-125. DOI: 10.3760/cma.j.cn101548-20200708-000107
Abstract
ObjectiveTo investigate the clinicopathological characteristics and prognostic factors of metastatic anorectal malignant melanoma after surgery.
MethodsA retrospective analysis of 52 patients diagnosed with metastatic anorectal malignant melanoma after surgery from January 2009 to January 2019 from Liaoning Cancer Hospital, Harbin Medical University Affiliated Tumor Hospital and Sun Yat-sen University Cancer Center. Log-rank test and cox model were used to conduct univariate and multivariate analysis to compare the impact of different clinical factors on the overall survival of patients.
ResultsThe follow-up period was 120 months. Log-rank univariate analysis showed that T stage, adjuvant therapy and the number of metastases were the influencing factors for the prognosis of metastatic anorectal malignant melanoma after surgery. T stage (OR=2.351, P=0.038) , adjuvant therapy (OR=0.073, P=0.041) and the number of metastatic tumors (OR=0.545, P= 0.016) were the independent factor for the metastatic anorectal malignancy melanoma.
ConclusionsT stage, adjuvant therapy and the number of metastases are independent factors that affected the prognosis of metastatic anorectal malignant melanoma after surgery. According to the patient’s condition and prognostic factors, adjustment of the treatment mode could prolong the patient’s overall survival time.
Key words:
Anorectal malignant melanoma; Metastasis; Surgery; Prognosis
Contributor Information
Liu Xin
Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital, Shenyang 110042, China
Qiao Jun
Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital, Shenyang 110042, China
Zhang Rui
Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital, Shenyang 110042, China
Si Lu
Peking University Cancer Hospital, Beijing 100142, China
Mao Lili
Peking University Cancer Hospital, Beijing 100142, China
Liu Yanlong
Harbin Medical University Cancer Hospital, Harbin 150081, China
Chi Zhaocheng
Jilin Cancer Hospital, Changchun 130012, China
Ding Peirong
Sun Yat-sen University Cancer Center, Guangzhou 510060, China
Chen Yu
Fujian Cancer Hospital, Fuzhou 350014, China
Liu Fang
Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital, Shenyang 110042, China
